PF3D7_0406700

Genome location: Pf3D7_04_v3:347,345..352,121(+)

Genome classification: Core

Function and Localization

Product Description: KLRAQ domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.05	0.98
Trophozoite	possibly expressed	0.50	0.72
Schizont	not expressed	0.46	0.74
Gametocyte	not expressed	0.62	0.67

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0406700

Resistome Missense Mutations: D189Y

Resistome Compounds with Missense Mutations: 3-Hydroxypropanamidine 22, Suloctidil

Resistome # Samples with Disruptive Mutations: 5 (5 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.119 | MFS: -3.106 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1004300)

Relative Growth Rate: 0.04 ± 0.04
Confidence: 7.96

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H492

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532451

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	9	39	25	51
disruptive	12	73	48	116
missense	12	73	46	102

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	14	85	32	63
disruptive	29	169	79	192
missense	22	145	69	138

PlasmoDB Total SNPs: 321

Non-coding: 261 | Synonymous: 39 | Nonsynonymous: 20 | Stop Codon: 1

Protein Information

Protein Length: 847 | Molecular Weight (kDa): 102.294

UniProt ID(s): C0H492

PDB ID(s): None

Isoelectric Point: 9.32

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR019343	Uncharacterised domain KLRAQ/TTKRSYEDQ, N-terminal
PFam	N/A	N/A
Superfamily	N/A	N/A