PF3D7_0406900

Genome location: Pf3D7_04_v3:353,655..359,878(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.10	0.95
Trophozoite	not expressed	0.08	0.96
Schizont	not expressed	0.08	0.96
Gametocyte	expressed	0.65	0.68

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0406900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.779 | #Insertions: 4

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H493

"Best" AlphaFill ligand hit: NHE (2-[n-cyclohexylamino]ethane sulfonic acid, Local RMSD=0.22) with 6EAE (Global RMSD=32.37)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533542

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	9	79	39	111
disruptive	51	268	138	354
missense	45	255	130	314

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	20	155	57	143
disruptive	106	569	248	471
missense	79	486	215	368

PlasmoDB Total SNPs: 231

Non-coding: 70 | Synonymous: 96 | Nonsynonymous: 65 | Stop Codon: 0

Protein Information

Protein Length: 1751 | Molecular Weight (kDa): 207.834

UniProt ID(s): C0H493

PDB ID(s): None

Isoelectric Point: 9.64

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A