PF3D7_0407000

Genome location: Pf3D7_04_v3:360,382..361,906(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.64	0.70
Trophozoite	not expressed	0.31	0.82
Schizont	not expressed	0.10	0.94
Gametocyte	not expressed	0.27	0.84

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0407000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.127 | MFS: -3.118 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q9U0L6

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533058

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	4	14	16	25
disruptive	18	57	37	74
missense	16	46	33	63

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	7	45	15	36
disruptive	38	124	49	114
missense	27	97	43	81

PlasmoDB Total SNPs: 72

Non-coding: 30 | Synonymous: 18 | Nonsynonymous: 24 | Stop Codon: 0

Protein Information

Protein Length: 405 | Molecular Weight (kDa): 48.567

UniProt ID(s): Q9U0L6

PDB ID(s): None

Isoelectric Point: 10.21

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A