Product Description: methyltransferase, putative
SignalP Peptide: N/A
# Transmembrane Domains: 1
EC Numbers: 2.1.1.201 (2-methoxy-6-polyprenyl-1,4-benzoquinol methylase)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005737 | cytoplasm |
| Component | GO:0005739 | mitochondrion |
| Function | GO:0008168 | methyltransferase activity |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.13 | 0.93 |
| Trophozoite | possibly expressed | 0.21 | 0.86 |
| Schizont | not expressed | 0.09 | 0.94 |
| Gametocyte | not expressed | 0.19 | 0.88 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0407100
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.786 | MFS: -2.53 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1004700)
Modification: Tagged | RMgm-4528
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C0H494
"Best" AlphaFill ligand hit: SAH (s-adenosyl-l-homocysteine, Local RMSD=5.13) with 1DL5 (Global RMSD=15.71)
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 2.1.1.201 | 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase | No BRENDA inhibitors |
No evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100787
Most Similar Human Ortholog: Q9H8H3
TM-align score: 0.74 | RMSD: 2.96
Seq Identity: 0.14 | Length: 212 / 333
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000170439 | methyltransferase like 7B |
| ENSG00000185432 | methyltransferase like 7A |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 21 | 11 | 25 |
| disruptive | 5 | 28 | 16 | 51 |
| missense | 5 | 26 | 15 | 47 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 9 | 31 | 28 | 27 |
| disruptive | 11 | 72 | 52 | 112 |
| missense | 9 | 62 | 43 | 66 |
PlasmoDB Total SNPs: 115
Non-coding: 75 | Synonymous: 30 | Nonsynonymous: 10 | Stop Codon: 0
Protein Length: 333 | Molecular Weight (kDa): 39.183
UniProt ID(s): C0H494
PDB ID(s): None
Isoelectric Point: 10.08
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR013216 | Methyltransferase type 11 |
| InterPro | IPR029063 | S-adenosyl-L-methionine-dependent methyltransferase |
| PFam | PF08241 | Methyltransferase type 11 |
| Superfamily | SSF53335 | S-adenosyl-L-methionine-dependent methyltransferase |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 30232409 | An in silico down-scaling approach uncovers novel constituents of thePlasmodium-containing vacuole. | Matz JM, Matuschewski K | 10.1038/s41598-018-32471-6 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |