PF3D7_0407300

Genome location: Pf3D7_04_v3:365,916..367,353(+)

Genome classification: Core

Function and Localization

Product Description: transcription factor, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005736	RNA polymerase I complex
Process	GO:0006363	termination of RNA polymerase I transcription

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	0.55	0.73
Trophozoite	not expressed	0.36	0.80
Schizont	possibly expressed	0.06	0.96
Gametocyte	not expressed	0.34	0.80

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0407300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.119 | MFS: -3.016 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1004900)

Relative Growth Rate: 0.06 ± 0.11
Confidence: 5.76

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q9U0L3

"Best" AlphaFill ligand hit: ANP (phosphoaminophosphonic acid-adenylate ester, Local RMSD=15.08) with 3LLT (Global RMSD=14.74)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_103317

Most Similar Human Ortholog: Q9P1U0

TM-align score: 0.47 | RMSD: 3.82

Seq Identity: 0.22 | Length: 81 / 320

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000066379	RNA polymerase I subunit H
ENSG00000206502	RNA polymerase I subunit H
ENSG00000224859	RNA polymerase I subunit H
ENSG00000233795	RNA polymerase I subunit H
ENSG00000235176	RNA polymerase I subunit H
ENSG00000235443	RNA polymerase I subunit H
ENSG00000236808	RNA polymerase I subunit H
ENSG00000236949	RNA polymerase I subunit H

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	19	5	21
disruptive	13	40	17	45
missense	11	39	17	43

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	2	29	22	27
disruptive	21	77	46	112
missense	19	68	34	81

PlasmoDB Total SNPs: 45

Non-coding: 21 | Synonymous: 15 | Nonsynonymous: 9 | Stop Codon: 0

Protein Information

Protein Length: 320 | Molecular Weight (kDa): 38.375

UniProt ID(s): Q9U0L3

PDB ID(s): None

Isoelectric Point: 7.79

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR001222	Zinc finger, TFIIS-type
InterPro	IPR034004	Pol I subunit A12, C-terminal zinc ribbon
PFam	PF01096	Zinc finger, TFIIS-type
Superfamily	SSF57783	N/A