PF3D7_0407400

Genome location: Pf3D7_04_v3:367,527..368,741(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	possibly expressed	0.07	0.97
Trophozoite	not expressed	0.33	0.80
Schizont	expressed	0.03	0.98
Gametocyte	not expressed	0.36	0.78

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0407400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: 0.358 | #Insertions: 5

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_1005000)

Relative Growth Rate: 0.79 ± 0.13
Confidence: 5.49

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1005000)

Modification: Disrupted | RMgm-2721

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q9U0L2

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533093

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 66

Non-coding: 57 | Synonymous: 5 | Nonsynonymous: 4 | Stop Codon: 0

Protein Information

Protein Length: 102 | Molecular Weight (kDa): 12.375

UniProt ID(s): Q9U0L2

PDB ID(s): None

Isoelectric Point: 10.89

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A