About Gene List

PF3D7_0407500

Genome location: Pf3D7_04_v3:369,885..371,270(+)

Genome classification: Core

Function and Localization

Product Description: mitochondrial carrier protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 3

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005739 mitochondrion

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite possibly expressed N/A N/A
Ring expressed 0.04 0.98
Trophozoite expressed 0.10 0.93
Schizont expressed 0.01 0.99
Gametocyte not expressed 0.09 0.95

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0407500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.145 | MFS: -3.036 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H498

"Best" AlphaFill ligand hit: SAH (s-adenosyl-l-homocysteine, Local RMSD=22.57) with 7LT5 (Global RMSD=23.61)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_101405

Most Similar Human Ortholog: F8WEL8

TM-align score: 0.69 | RMSD: 1.47

Seq Identity: 0.08 | Length: 37 / 380

All Human Orthologs (OrthoMCL):

Gene ID Description
ENSG00000013306 solute carrier family 25 member 39
ENSG00000075303 solute carrier family 25 member 40

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 1 23 6 27
disruptive 2 13 21 27
missense 2 12 16 23

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 6 42 18 46
disruptive 5 61 51 101
missense 4 40 44 67

PlasmoDB Total SNPs: 43

Non-coding: 20 | Synonymous: 18 | Nonsynonymous: 5 | Stop Codon: 0

Protein Information

Protein Length: 380 | Molecular Weight (kDa): 45.3

UniProt ID(s): C0H498

PDB ID(s): None

Isoelectric Point: 10.04

Protein Domain Annotations:

Source Family ID Description
InterPro IPR002067 Mitochondrial carrier protein
InterPro IPR018108 Mitochondrial substrate/solute carrier
InterPro IPR023395 Mitochondrial carrier domain superfamily
PFam PF00153 Mitochondrial substrate/solute carrier
Superfamily SSF103506 Mitochondrial carrier domain superfamily

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
34494883 A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. van Esveld SL, Meerstein-Kessel L, ..., Huynen MA 10.1128/mSphere.00614-21