PF3D7_0407600

Genome location: Pf3D7_04_v3:373,039..376,677(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	not expressed	0.04	0.98
Trophozoite	not expressed	0.05	0.97
Schizont	not expressed	0.06	0.96
Gametocyte	possibly expressed	0.41	0.77

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0407600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.501 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1005200)

Modification: Disrupted | RMgm-2722

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q9U0L0

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533466

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	13	62	34	63
disruptive	56	278	112	284
missense	31	219	90	224

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	27	125	50	86
disruptive	119	565	194	511
missense	67	423	145	288

PlasmoDB Total SNPs: 207

Non-coding: 0 | Synonymous: 95 | Nonsynonymous: 112 | Stop Codon: 0

Protein Information

Protein Length: 1212 | Molecular Weight (kDa): 142.862

UniProt ID(s): Q9U0L0

PDB ID(s): None

Isoelectric Point: 5.34

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A