About Gene List

PF3D7_0407800 (CINCH)

Genome location: Pf3D7_04_v3:384,240..391,362(+)

Genome classification: Core

Function and Localization

Product Description: protein CINCH

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0045178 basal part of cell
Component GO:0070258 inner membrane pellicle complex
Component GO:0005634 nucleus
Function GO:0005515 protein binding
Process GO:0051301 cell division

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring not expressed 0.14 0.93
Trophozoite expressed 0.54 0.73
Schizont expressed 2.99 0.06
Gametocyte expressed 0.93 0.53

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0407800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 5 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.22 | MFS: -2.733 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q9U0K8

"Best" AlphaFill ligand hit: A2P (adenosine-2'-5'-diphosphate, Local RMSD=0.78) with 3JQQ (Global RMSD=29.89)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_179327

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 28 78 54 109
disruptive 113 279 139 352
missense 55 192 108 268

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 40 154 74 130
disruptive 185 505 230 454
missense 92 359 174 332

PlasmoDB Total SNPs: 390

Non-coding: 65 | Synonymous: 154 | Nonsynonymous: 171 | Stop Codon: 0

Protein Information

Protein Length: 1960 | Molecular Weight (kDa): 230.124

UniProt ID(s): Q9U0K8

PDB ID(s): None

Isoelectric Point: 6.89

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108
31097714 An essential contractile ring protein controls cell division in Plasmodiumfalciparum. Rudlaff RM, Kraemer S, Streva VA, Dvorin JD 10.1038/s41467-019-10214-z