PF3D7_0408000

Genome location: Pf3D7_04_v3:394,047..394,714(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.35	0.87
Trophozoite	not expressed	0.03	0.98
Schizont	not expressed	0.21	0.91
Gametocyte	not expressed	0.14	0.92

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0408000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.418 | MFS: -2.249 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q9U0K6

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533100

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	7	3	8
disruptive	8	21	4	28
missense	7	21	4	24

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	1	13	9	15
disruptive	14	36	12	43
missense	12	31	11	32

PlasmoDB Total SNPs: 24

Non-coding: 14 | Synonymous: 4 | Nonsynonymous: 6 | Stop Codon: 0

Protein Information

Protein Length: 171 | Molecular Weight (kDa): 20.863

UniProt ID(s): Q9U0K6

PDB ID(s): None

Isoelectric Point: 10.14

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A