About Gene List

PF3D7_0408100

Genome location: Pf3D7_04_v3:396,410..401,290(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.43 0.79
Trophozoite not expressed 0.25 0.85
Schizont not expressed 0.28 0.82
Gametocyte not expressed 0.44 0.75

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0408100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.888 | #Insertions: 4

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1005700)

Modification: Disrupted | RMgm-2725

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q9U0K5

"Best" AlphaFill ligand hit: PH2 (2-amino-6-hydroxymethyl-7,8-dihydro-3h-pteridin-4-one, Local RMSD=0.02) with 6JWR (Global RMSD=8.57)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532780

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 11 43 20 52
disruptive 44 125 90 233
missense 27 113 82 201

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 16 88 39 75
disruptive 73 340 171 325
missense 36 289 133 202

PlasmoDB Total SNPs: 181

Non-coding: 60 | Synonymous: 63 | Nonsynonymous: 58 | Stop Codon: 0

Protein Information

Protein Length: 1121 | Molecular Weight (kDa): 133.601

UniProt ID(s): Q9U0K5

PDB ID(s): None

Isoelectric Point: 5.42

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104