PF3D7_0408200

Genome location: Pf3D7_04_v3:401,320..403,441(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.08	0.95
Trophozoite	not expressed	0.06	0.97
Schizont	not expressed	0.08	0.94
Gametocyte	expressed	0.63	0.68

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0408200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.196 | MFS: -2.626 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q9U0K4

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_104916

Most Similar Human Ortholog: H0YND2

TM-align score: 0.86 | RMSD: 1.75

Seq Identity: 0.10 | Length: 102 / 622

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000151575	testis expressed 9

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	26	13	28
disruptive	15	68	44	113
missense	12	68	41	101

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	3	55	17	33
disruptive	34	156	80	153
missense	23	129	63	113

PlasmoDB Total SNPs: 80

Non-coding: 29 | Synonymous: 32 | Nonsynonymous: 19 | Stop Codon: 0

Protein Information

Protein Length: 622 | Molecular Weight (kDa): 73.277

UniProt ID(s): Q9U0K4

PDB ID(s): None

Isoelectric Point: 9.23

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A