Product Description: zinc finger Ran-binding domain-containing protein 2, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005634 | nucleus |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.27 | 0.87 |
| Trophozoite | not expressed | 0.50 | 0.71 |
| Schizont | not expressed | 0.36 | 0.78 |
| Gametocyte | expressed | 0.61 | 0.66 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0408300
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 1 | MFS: -1.863 | #Insertions: 0
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1005900)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1005900)
Modification: Disrupted | RMgm-2726
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q9U0K3
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_106338
Most Similar Human Ortholog: O95218
TM-align score: 0.18 | RMSD: 5.08
Seq Identity: 0.25 | Length: 83 / 344
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000132485 | zinc finger RANBP2-type containing 2 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 18 | 6 | 21 |
| disruptive | 9 | 25 | 27 | 61 |
| missense | 3 | 21 | 24 | 49 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 8 | 35 | 8 | 12 |
| disruptive | 18 | 78 | 46 | 80 |
| missense | 6 | 68 | 39 | 52 |
PlasmoDB Total SNPs: 161
Non-coding: 106 | Synonymous: 52 | Nonsynonymous: 3 | Stop Codon: 0
Protein Length: 344 | Molecular Weight (kDa): 42.215
UniProt ID(s): Q9U0K3
PDB ID(s): None
Isoelectric Point: 9.6
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001876 | Zinc finger, RanBP2-type |
| InterPro | IPR017337 | Uncharacterised conserved protein UCP037956, zinc finger Ran-binding |
| InterPro | IPR036443 | Zinc finger, RanBP2-type superfamily |
| PFam | PF00641 | Zinc finger, RanBP2-type |
| Superfamily | SSF90209 | Zinc finger, RanBP2-type superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 26740623 | Identification of the Zinc Finger Protein ZRANB2 as a Novel MaternalLipopolysaccharide-binding Protein That Protects Embryos of Zebrafish againstGram-negative Bacterial Infections | Wang X, Du X, Li H, Zhang S | 10.1074/jbc.M115.679167 |