PF3D7_0408400

Genome location: Pf3D7_04_v3:405,513..408,243(-)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005739	mitochondrion

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.03	0.98
Trophozoite	expressed	0.31	0.81
Schizont	possibly expressed	0.06	0.96
Gametocyte	possibly expressed	0.37	0.78

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0408400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.127 | MFS: -2.866 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1006000)

Relative Growth Rate: 0.13 ± 0.04
Confidence: 7.67

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H499

"Best" AlphaFill ligand hit: NAD (nicotinamide-adenine-dinucleotide, Local RMSD=3.57) with 1ZSN (Global RMSD=11.66)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_215322

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	23	10	20
disruptive	3	25	25	56
missense	3	24	25	49

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	4	42	14	26
disruptive	8	85	44	128
missense	4	73	37	86

PlasmoDB Total SNPs: 73

Non-coding: 50 | Synonymous: 21 | Nonsynonymous: 2 | Stop Codon: 0

Protein Information

Protein Length: 471 | Molecular Weight (kDa): 57.266

UniProt ID(s): C0H499

PDB ID(s): None

Isoelectric Point: 9.4

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
12368867	Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.	Hall N, Pain A, ..., Barrell BG	10.1038/nature01095
34494883	A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology.	van Esveld SL, Meerstein-Kessel L, ..., Huynen MA	10.1128/mSphere.00614-21