PF3D7_0408800

Genome location: Pf3D7_04_v3:422,011..422,958(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: MKILNLILLSIIFLKYYHVCC

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.00	1.00
Trophozoite	not expressed	0.00	1.00
Schizont	not expressed	0.00	1.00
Gametocyte	not expressed	0.03	0.98

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0408800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.892 | MFS: -2.905 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1006400)

Relative Growth Rate: 1.04 ± 0.10
Confidence: 5.96

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1006400)

Modification: Disrupted | RMgm-2731

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q9U0J8

"Best" AlphaFill ligand hit: AMP (adenosine monophosphate, Local RMSD=8.98) with 5DZT (Global RMSD=21.32)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533291

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	0	12	7	14
disruptive	9	29	11	38
missense	6	25	10	33

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	2	28	3	22
disruptive	17	59	39	76
missense	11	42	31	61

PlasmoDB Total SNPs: 29

Non-coding: 0 | Synonymous: 25 | Nonsynonymous: 3 | Stop Codon: 1

Protein Information

Protein Length: 315 | Molecular Weight (kDa): 37.42

UniProt ID(s): Q9U0J8

PDB ID(s): None

Isoelectric Point: 4.58

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A