PF3D7_0409000

Genome location: Pf3D7_04_v3:427,283..435,517(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.19	0.91
Trophozoite	possibly expressed	0.45	0.75
Schizont	possibly expressed	0.34	0.81
Gametocyte	not expressed	0.31	0.82

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0409000

Resistome Missense Mutations: I475S, H476N

Resistome Compounds with Missense Mutations: AN13956

Resistome # Samples with Disruptive Mutations: 1 (1 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.787 | #Insertions: 15

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q9U0J6

"Best" AlphaFill ligand hit: ZOL (zoledronic acid, Local RMSD=0.75) with 2Q58 (Global RMSD=16.65)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533501

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	21	102	67	146
disruptive	159	414	230	505
missense	94	317	194	422

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	42	195	109	168
disruptive	286	849	358	711
missense	143	642	292	507

PlasmoDB Total SNPs: 299

Non-coding: 28 | Synonymous: 136 | Nonsynonymous: 135 | Stop Codon: 0

Protein Information

Protein Length: 2567 | Molecular Weight (kDa): 312.503

UniProt ID(s): Q9U0J6

PDB ID(s): None

Isoelectric Point: 9.6

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A