Product Description: U4/U6 small nuclear ribonucleoprotein PRP31, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005687 | U4 snRNP |
| Component | GO:0046540 | U4/U6 x U5 tri-snRNP complex |
| Component | GO:0071011 | precatalytic spliceosome |
| Component | GO:0005681 | spliceosomal complex |
| Component | GO:0097526 | spliceosomal tri-snRNP complex |
| Process | GO:0008380 | RNA splicing |
| Process | GO:0000375 | RNA splicing, via transesterification reactions |
| Process | GO:0000398 | mRNA splicing, via spliceosome |
| Process | GO:0000387 | spliceosomal snRNP assembly |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 1.39 | 0.41 |
| Trophozoite | expressed | 1.15 | 0.42 |
| Schizont | expressed | 0.72 | 0.60 |
| Gametocyte | expressed | 0.76 | 0.59 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0409100
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.125 | MFS: -3.04 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1006700)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C0H4A0
"Best" AlphaFill ligand hit: SAM (s-adenosylmethionine, Local RMSD=1.42) with 3NMU (Global RMSD=9.80)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102494
Most Similar Human Ortholog: E7ESX0
TM-align score: 0.74 | RMSD: 2.59
Seq Identity: 0.29 | Length: 226 / 534
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000105618 | pre-mRNA processing factor 31 |
| ENSG00000274144 | pre-mRNA processing factor 31 |
| ENSG00000274651 | pre-mRNA processing factor 31 |
| ENSG00000274894 | pre-mRNA processing factor 31 |
| ENSG00000275117 | pre-mRNA processing factor 31 |
| ENSG00000275885 | pre-mRNA processing factor 31 |
| ENSG00000276421 | pre-mRNA processing factor 31 |
| ENSG00000277154 | pre-mRNA processing factor 31 |
| ENSG00000277707 | pre-mRNA processing factor 31 |
| ENSG00000277953 | pre-mRNA processing factor 31 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 5 | 30 | 14 | 31 |
| disruptive | 11 | 40 | 29 | 62 |
| missense | 9 | 32 | 29 | 52 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 8 | 52 | 25 | 34 |
| disruptive | 21 | 82 | 57 | 101 |
| missense | 15 | 62 | 48 | 74 |
PlasmoDB Total SNPs: 114
Non-coding: 82 | Synonymous: 23 | Nonsynonymous: 9 | Stop Codon: 0
Protein Length: 534 | Molecular Weight (kDa): 61.475
UniProt ID(s): C0H4A0
PDB ID(s): None
Isoelectric Point: 5.21
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR002687 | Nop domain |
| InterPro | IPR012976 | NOSIC |
| InterPro | IPR019175 | Prp31 C-terminal |
| InterPro | IPR027105 | U4/U6 small nuclear ribonucleoprotein Prp31 |
| InterPro | IPR036070 | Nop domain superfamily |
| PFam | PF01798 | Nop domain |
| PFam | PF09785 | Prp31 C-terminal |
| Superfamily | SSF89124 | Nop domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |