Product Description: protein SOF1, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0080008 | Cul4-RING E3 ubiquitin ligase complex |
| Component | GO:0005730 | nucleolus |
| Component | GO:0032040 | small-subunit processome |
| Component | GO:0005732 | sno(s)RNA-containing ribonucleoprotein complex |
| Process | GO:0000462 | maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) |
| Process | GO:0000154 | rRNA modification |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.84 | 0.60 |
| Trophozoite | expressed | 0.60 | 0.66 |
| Schizont | expressed | 0.26 | 0.83 |
| Gametocyte | expressed | 0.86 | 0.55 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0409200
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.198 | MFS: -2.798 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1006800)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q9U0J4
"Best" AlphaFill ligand hit: ALQ (2-methyl-propionic acid, Local RMSD=1.79) with 4GM8 (Global RMSD=3.58)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102358
Most Similar Human Ortholog: Q9NV06
TM-align score: 0.98 | RMSD: 1.36
Seq Identity: 0.42 | Length: 444 / 482
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000164934 | DDB1 and CUL4 associated factor 13 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 9 | 30 | 12 | 33 |
| disruptive | 6 | 25 | 12 | 40 |
| missense | 6 | 25 | 11 | 37 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 13 | 54 | 26 | 21 |
| disruptive | 9 | 61 | 20 | 82 |
| missense | 8 | 51 | 17 | 67 |
PlasmoDB Total SNPs: 43
Non-coding: 17 | Synonymous: 21 | Nonsynonymous: 5 | Stop Codon: 0
Protein Length: 482 | Molecular Weight (kDa): 56.661
UniProt ID(s): Q9U0J4
PDB ID(s): None
Isoelectric Point: 9.67
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001680 | WD40 repeat |
| InterPro | IPR007287 | Sof1-like protein |
| InterPro | IPR019775 | WD40 repeat, conserved site |
| InterPro | IPR036322 | WD40-repeat-containing domain superfamily |
| PFam | PF00400 | WD40 repeat |
| PFam | PF04158 | Sof1-like protein |
| Superfamily | SSF50978 | WD40-repeat-containing domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 11353602 | Oxacillinase-mediated resistance to cefepime and susceptibility to ceftazidime inPseudomonas aeruginosa | Aubert D, Poirel L, ..., Nordmann P | 10.1128/AAC.45.6.1615-1620.2001 |
| 16524898 | Saccharomyces cerevisiae Sof1p associates with 35S Pre-rRNA independent from U3snoRNA and Rrp5p | Bax R, Vos HR, Raue HA, Vos JC | 10.1128/EC.5.3.427-434.2006 |
| 17158738 | Small-subunit rRNA processome proteins are translationally regulated duringdifferentiation of Trypanosoma cruzi | Nardelli SC, Avila AR, ..., Dallagiovanna B | 10.1128/EC.00279-06 |