Product Description: 3-ketodihydrosphingosine reductase, putative
SignalP Peptide: N/A
# Transmembrane Domains: 3
EC Numbers: 1.1.1.102 (3-dehydrosphinganine reductase)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020011 | apicoplast |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | no data | N/A | N/A |
| Ring | no data | 0.08 | 0.96 |
| Trophozoite | no data | 0.65 | 0.64 |
| Schizont | no data | 0.35 | 0.78 |
| Gametocyte | no data | 0.53 | 0.70 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0409500
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.127 | MFS: -2.948 | #Insertions: 0
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1007100)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1007100)
Modification: Disrupted | RMgm-2737
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C0H4A1
"Best" AlphaFill ligand hit: NAP (nadp nicotinamide-adenine-dinucleotide phosphate, Local RMSD=0.80) with 6NKK (Global RMSD=3.13)
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 1.1.1.102 | 3-dehydrosphinganine reductase | siRNA |
No evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102003
Most Similar Human Ortholog: Q06136
TM-align score: 0.89 | RMSD: 2.57
Seq Identity: 0.26 | Length: 323 / 398
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000119537 | 3-ketodihydrosphingosine reductase |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 16 | 7 | 17 |
| disruptive | 1 | 13 | 8 | 21 |
| missense | 1 | 12 | 5 | 16 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 32 | 16 | 16 |
| disruptive | 9 | 43 | 20 | 84 |
| missense | 2 | 28 | 18 | 46 |
PlasmoDB Total SNPs: 133
Non-coding: 115 | Synonymous: 17 | Nonsynonymous: 1 | Stop Codon: 0
Protein Length: 398 | Molecular Weight (kDa): 46.79
UniProt ID(s): C0H4A1
PDB ID(s): None
Isoelectric Point: 9.71
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR002347 | Short-chain dehydrogenase/reductase SDR |
| InterPro | IPR013968 | Polyketide synthase, ketoreductase domain |
| InterPro | IPR036291 | NAD(P)-binding domain superfamily |
| PFam | PF00106 | Short-chain dehydrogenase/reductase SDR |
| PFam | PF08659 | Polyketide synthase, ketoreductase domain |
| Superfamily | SSF51735 | NAD(P)-binding domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 30212465 | Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites. | Boucher MJ, Ghosh S, ..., Yeh E | 10.1371/journal.pbio.2005895 |