Product Description: zinc finger protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005634 | nucleus |
| Component | GO:0030687 | preribosome, large subunit precursor |
| Process | GO:0042273 | ribosomal large subunit biogenesis |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | expressed | 0.73 | 0.66 |
| Trophozoite | expressed | 0.60 | 0.66 |
| Schizont | expressed | 1.53 | 0.39 |
| Gametocyte | possibly expressed | 0.78 | 0.58 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0409800
Resistome Missense Mutations: L91F
Resistome Compounds with Missense Mutations: MMV665794
Resistome # Samples with Disruptive Mutations: 3 (3 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.119 | MFS: -3.047 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q9U0I8
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101830
Most Similar Human Ortholog: Q969S3
TM-align score: 0.33 | RMSD: 5.08
Seq Identity: 0.21 | Length: 197 / 575
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000173545 | zinc finger protein 622 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 9 | 22 | 15 | 26 |
| disruptive | 13 | 46 | 28 | 84 |
| missense | 12 | 45 | 28 | 73 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 11 | 53 | 15 | 28 |
| disruptive | 28 | 121 | 55 | 146 |
| missense | 22 | 98 | 45 | 96 |
PlasmoDB Total SNPs: 210
Non-coding: 158 | Synonymous: 28 | Nonsynonymous: 24 | Stop Codon: 0
Protein Length: 575 | Molecular Weight (kDa): 68.533
UniProt ID(s): Q9U0I8
PDB ID(s): None
Isoelectric Point: 9.42
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR036236 | Zinc finger C2H2 superfamily |
| InterPro | IPR040025 | Zinc finger protein 622/Rei1/Reh1 |
| InterPro | IPR041661 | ZN622/Rei1/Reh1, zinc finger C2H2-type |
| PFam | PF12756 | ZN622/Rei1/Reh1, zinc finger C2H2-type |
| Superfamily | SSF57667 | Zinc finger C2H2 superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |