About Gene List

PF3D7_0410000 (EVP1)

Genome location: Pf3D7_04_v3:464,039..468,171(-)

Genome classification: Core

Function and Localization

Product Description: erythrocyte vesicle protein 1

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0044161 host cell cytoplasmic vesicle
Component GO:0044164 host cell cytosol

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring expressed 1.12 0.54
Trophozoite expressed 0.33 0.83
Schizont expressed 0.86 0.63
Gametocyte not expressed 0.52 0.71

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0410000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.859 | MFS: -2.864 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1007600)

Modification: Disrupted | RMgm-2740

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q9U0I6

"Best" AlphaFill ligand hit: ATP (adenosine-5'-triphosphate, Local RMSD=4.06) with 6JWQ (Global RMSD=17.60)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_153933

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 7 15 10 30
disruptive 64 53 21 65
missense 34 36 18 32

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 7 39 14 36
disruptive 83 84 27 95
missense 42 52 20 48

PlasmoDB Total SNPs: 362

Non-coding: 220 | Synonymous: 77 | Nonsynonymous: 65 | Stop Codon: 0

Protein Information

Protein Length: 833 | Molecular Weight (kDa): 100.543

UniProt ID(s): Q9U0I6

PDB ID(s): None

Isoelectric Point: 7.17

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
18551176 The malaria secretome: from algorithms to essential function in blood stageinfection. van Ooij C, Tamez P, ..., Haldar K https://pubmed.ncbi.nlm.nih.gov/18551176/
18688278 An erythrocyte vesicle protein exported by the malaria parasite promotestubovesicular lipid import from the host cell surface. Tamez PA, Bhattacharjee S, ..., Haldar K 10.1371/journal.ppat.1000118