Product Description: protein phosphatase PPM1, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 3.1.3.16 (Protein-serine/threonine phosphatase)
Curated GO (PlasmoDB):
Type | GO Term | Name |
---|---|---|
Component | GO:0005737 | cytoplasm |
Component | GO:0005634 | nucleus |
Function | GO:0004724 | magnesium-dependent protein serine/threonine phosphatase activity |
Function | GO:0004721 | phosphoprotein phosphatase activity |
Function | GO:0004722 | protein serine/threonine phosphatase activity |
Process | GO:0006470 | protein dephosphorylation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
Stage | LR class | MCA mean | MCA prop. zeros |
---|---|---|---|
Sporozoite | expressed | N/A | N/A |
Ring | expressed | 0.36 | 0.82 |
Trophozoite | expressed | 0.50 | 0.71 |
Schizont | expressed | 0.20 | 0.87 |
Gametocyte | expressed | 0.36 | 0.79 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0410300
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -2.399 | #Insertions: 2
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1007700)
Modification: Disrupted | RMgm-2741
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q9U0I5
"Best" AlphaFill ligand hit: No AlphaFill hits
BRENDA EC Inhibitors:
EC # | Name | EC Inhibitors |
---|---|---|
3.1.3.16 | protein-serine/threonine phosphatase | ATPADPUDPAMPGTPUTPUMPNaFEDTAEGTAcAMPNADPH... |
No evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 3 | 41 | 33 | 48 |
disruptive | 35 | 103 | 63 | 146 |
missense | 19 | 82 | 60 | 112 |
Any inclusion in genotype call
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 10 | 87 | 42 | 47 |
disruptive | 65 | 198 | 108 | 222 |
missense | 34 | 158 | 91 | 157 |
PlasmoDB Total SNPs: 268
Non-coding: 153 | Synonymous: 56 | Nonsynonymous: 59 | Stop Codon: 0
Protein Length: 906 | Molecular Weight (kDa): 105.199
UniProt ID(s): Q9U0I5
PDB ID(s): None
Isoelectric Point: 6.95
Protein Domain Annotations:
Source | Family ID | Description |
---|---|---|
InterPro | IPR001932 | PPM-type phosphatase domain |
InterPro | IPR015655 | Protein phosphatase 2C family |
InterPro | IPR036457 | PPM-type phosphatase domain superfamily |
PFam | PF00481 | PPM-type phosphatase domain |
Superfamily | SSF69349 | PPM-type phosphatase domain superfamily |
Superfamily | SSF81606 |
PMID | Title | Authors | DOI/Link |
---|---|---|---|
12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
25011111 | Genome-wide functional analysis of Plasmodium protein phosphatases reveals keyregulators of parasite development and differentiation. | Guttery DS, Poulin B, ..., Tewari R | 10.1016/j.chom.2014.05.020 |