About Gene List

PF3D7_0410300 (PPM1)

Genome location: Pf3D7_04_v3:470,021..473,920(-)

Genome classification: Core

Function and Localization

Product Description: protein phosphatase PPM1, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: 3.1.3.16 (Protein-serine/threonine phosphatase)

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005737 cytoplasm
Component GO:0005634 nucleus
Function GO:0004724 magnesium-dependent protein serine/threonine phosphatase activity
Function GO:0004721 phosphoprotein phosphatase activity
Function GO:0004722 protein serine/threonine phosphatase activity
Process GO:0006470 protein dephosphorylation

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring expressed 0.36 0.82
Trophozoite expressed 0.50 0.71
Schizont expressed 0.20 0.87
Gametocyte expressed 0.36 0.79

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0410300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.399 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1007700)

Modification: Disrupted | RMgm-2741

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q9U0I5

"Best" AlphaFill ligand hit: No AlphaFill hits

BRENDA EC Inhibitors:

EC # Name EC Inhibitors
3.1.3.16 protein-serine/threonine phosphatase ATPADPUDPAMPGTPUTPUMPNaFEDTAEGTAcAMPNADPH...

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_154815

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 3 41 33 48
disruptive 35 103 63 146
missense 19 82 60 112

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 10 87 42 47
disruptive 65 198 108 222
missense 34 158 91 157

PlasmoDB Total SNPs: 268

Non-coding: 153 | Synonymous: 56 | Nonsynonymous: 59 | Stop Codon: 0

Protein Information

Protein Length: 906 | Molecular Weight (kDa): 105.199

UniProt ID(s): Q9U0I5

PDB ID(s): None

Isoelectric Point: 6.95

Protein Domain Annotations:

Source Family ID Description
InterPro IPR001932 PPM-type phosphatase domain
InterPro IPR015655 Protein phosphatase 2C family
InterPro IPR036457 PPM-type phosphatase domain superfamily
PFam PF00481 PPM-type phosphatase domain
Superfamily SSF69349 PPM-type phosphatase domain superfamily
Superfamily SSF81606

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
25011111 Genome-wide functional analysis of Plasmodium protein phosphatases reveals keyregulators of parasite development and differentiation. Guttery DS, Poulin B, ..., Tewari R 10.1016/j.chom.2014.05.020