Product Description: exosome complex component RRP4
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0031499 | TRAMP complex |
| Component | GO:0005737 | cytoplasm |
| Component | GO:0000177 | cytoplasmic exosome (RNase complex) |
| Component | GO:0000178 | exosome (RNase complex) |
| Component | GO:0000176 | nuclear exosome (RNase complex) |
| Function | GO:0000175 | 3'-5'-exoribonuclease activity |
| Function | GO:0003723 | RNA binding |
| Function | GO:0005515 | protein binding |
| Process | GO:0071034 | CUT catabolic process |
| Process | GO:0034475 | U4 snRNA 3'-end processing |
| Process | GO:0043928 | exonucleolytic catabolism of deadenylated mRNA |
| Process | GO:0000467 | exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) |
| Process | GO:0071035 | nuclear polyadenylation-dependent rRNA catabolic process |
| Process | GO:0071038 | nuclear polyadenyl |
| Process | GO:0071049 | |
| Process | GO:0034427 | |
| Process | GO:0071051 | |
| Process | GO:0006364 |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.03 | 0.98 |
| Trophozoite | expressed | 0.04 | 0.97 |
| Schizont | expressed | 0.01 | 1.00 |
| Gametocyte | expressed | 0.08 | 0.95 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0410400
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.154 | MFS: -2.939 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1007800)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q9U0I4
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101400
Most Similar Human Ortholog: Q13868
TM-align score: 0.90 | RMSD: 2.68
Seq Identity: 0.31 | Length: 290 / 338
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000130713 | exosome component 2 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 20 | 14 | 19 |
| disruptive | 1 | 14 | 11 | 41 |
| missense | 1 | 14 | 11 | 33 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 8 | 35 | 7 | 25 |
| disruptive | 4 | 43 | 25 | 85 |
| missense | 2 | 36 | 23 | 54 |
PlasmoDB Total SNPs: 93
Non-coding: 68 | Synonymous: 22 | Nonsynonymous: 3 | Stop Codon: 0
Protein Length: 338 | Molecular Weight (kDa): 38.761
UniProt ID(s): Q9U0I4
PDB ID(s): None
Isoelectric Point: 8.51
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR004088 | K Homology domain, type 1 |
| InterPro | IPR012340 | Nucleic acid-binding, OB-fold |
| InterPro | IPR022967 | RNA-binding domain, S1 |
| InterPro | IPR026699 | Exosome complex RNA-binding protein 1/RRP40/RRP4 |
| InterPro | IPR036612 | K Homology domain, type 1 superfamily |
| PFam | PF15985 | K Homology domain, type 1 |
| Superfamily | SSF110324 | Nucleic acid-binding, OB-fold |
| Superfamily | SSF50249 | K Homology domain, type 1 superfamily |
| Superfamily | SSF54791 |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 29664138 | Characterization of the Catalytic Subunits of the RNA Exosome-like Complex inPlasmodium falciparum. | Jiang N, Yu S, ..., Chen Q | 10.1111/jeu.12625 |
| 30235972 | Disruption of the RNA exosome reveals the hidden face of the malaria parasitetranscriptome. | Droll D, Wei G, ..., Zhang Q | 10.1080/15476286.2018.1517014 |
| 32079470 | The cryptic unstable transcripts are associated with developmentally regulatedgene expression in blood-stage Plasmodium falciparum. | Yin S, Fan Y, ..., Zhang Q | 10.1080/15476286.2020.1732032 |
| 37904946 | Comparative analyses of disease-linked missense mutations in the RNA exosomemodeled in budding yeast reveal distinct functional consequences in translation | Sterrett MC, Cureton LA, ..., Ghalei H | 10.18.562946 |
| 36861343 | In vivo characterization of the critical interaction between the RNA exosome andthe essential RNA helicase Mtr4 in Saccharomyces cerevisiae | Sterrett MC, Farchi D, ..., Corbett AH | 10.1093/g3journal/jkad049 |
| 34162742 | A budding yeast model for human disease mutations in the EXOSC2 cap subunit ofthe RNA exosome complex | Sterrett MC, Enyenihi L, ..., Corbett AH | 10.1261/rna.078618.120 |