PF3D7_0410500

Genome location: Pf3D7_04_v3:475,944..476,585(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005737	cytoplasm

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.01	0.99
Trophozoite	possibly expressed	0.02	0.99
Schizont	not expressed	0.04	0.97
Gametocyte	possibly expressed	0.24	0.85

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0410500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.119 | MFS: -2.819 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1007900)

Relative Growth Rate: 1.02 ± 0.12
Confidence: 5.67

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1007900)

Modification: Disrupted | RMgm-2743

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q9U0I3

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_104556

Most Similar Human Ortholog: Q8IUD2

TM-align score: 0.71 | RMSD: 3.07

Seq Identity: 0.11 | Length: 183 / 213

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000082805	ELKS/RAB6-interacting/CAST family member 1
ENSG00000187672	ELKS/RAB6-interacting/CAST family member 2

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	10	8	11
disruptive	5	9	4	19
missense	5	9	4	19

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	6	14	9	14
disruptive	7	22	13	37
missense	7	21	11	33

PlasmoDB Total SNPs: 6

Non-coding: 0 | Synonymous: 3 | Nonsynonymous: 3 | Stop Codon: 0

Protein Information

Protein Length: 213 | Molecular Weight (kDa): 25.377

UniProt ID(s): Q9U0I3

PDB ID(s): None

Isoelectric Point: 10.5

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A