Product Description: armadillo-type repeat protein ATRP
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0071944 | cell periphery |
| Component | GO:0005737 | cytoplasm |
| Component | GO:0005783 | endoplasmic reticulum |
| Component | GO:0070258 | inner membrane pellicle complex |
| Function | GO:0000774 | adenyl-nucleotide exchange factor activity |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.07 | 0.97 |
| Trophozoite | expressed | 0.14 | 0.92 |
| Schizont | expressed | 0.12 | 0.92 |
| Gametocyte | expressed | 0.15 | 0.91 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0410600
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.16 | MFS: -3.223 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q9U0I2
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_103411
Most Similar Human Ortholog: K7EN20
TM-align score: 0.88 | RMSD: 1.40
Seq Identity: 0.21 | Length: 96 / 326
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000133265 | HSPA (Hsp70) binding protein 1 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 15 | 13 | 13 |
| disruptive | 0 | 9 | 8 | 23 |
| missense | 0 | 9 | 8 | 21 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 39 | 10 | 18 |
| disruptive | 2 | 20 | 18 | 63 |
| missense | 2 | 17 | 15 | 43 |
PlasmoDB Total SNPs: 112
Non-coding: 107 | Synonymous: 4 | Nonsynonymous: 1 | Stop Codon: 0
Protein Length: 326 | Molecular Weight (kDa): 37.065
UniProt ID(s): Q9U0I2
PDB ID(s): None
Isoelectric Point: 5.89
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR016024 | Armadillo-type fold |
| PFam | N/A | N/A |
| Superfamily | SSF48371 | Armadillo-type fold |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 32266165 | Molecular Characterization and Immuno-Reactivity Patterns of a Novel Plasmodiumfalciparum Armadillo-Type Repeat Protein, PfATRP. | Amlabu E, Ilani P, ..., Awandare GA | 10.3389/fcimb.2020.00114 |