About Gene List

PF3D7_0410800 (AKIT3)

Genome location: Pf3D7_04_v3:484,937..489,959(+)

Genome classification: Core

Function and Localization

Product Description: apicomplexan kinetochore protein 3, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0000776 kinetochore
Component GO:0005634 nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring expressed 0.17 0.92
Trophozoite expressed 0.63 0.64
Schizont expressed 1.61 0.28
Gametocyte expressed 0.72 0.62

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0410800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.131 | MFS: -2.926 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0612200)

Modification: Tagged | RMgm-5115

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q9U0I0

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533086

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 18 75 33 65
disruptive 113 172 102 236
missense 48 130 78 173

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 35 131 55 90
disruptive 164 370 170 388
missense 71 281 130 234

PlasmoDB Total SNPs: 293

Non-coding: 84 | Synonymous: 125 | Nonsynonymous: 84 | Stop Codon: 0

Protein Information

Protein Length: 1298 | Molecular Weight (kDa): 150.27

UniProt ID(s): O00895, Q9U0I0

PDB ID(s): None

Isoelectric Point: 6.58

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108
36006241 Composition and organization of kinetochores show plasticity in apicomplexanchromosome segregation Brusini L, Dos Santos Pacheco N, ..., Brochet M 10.1083/jcb.202111084