About Gene List

PF3D7_0410900 (AKIT7)

Genome location: Pf3D7_04_v3:490,388..494,260(-)

Genome classification: Core

Function and Localization

Product Description: apicomplexan kinetochore protein 7, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0000776 kinetochore
Component GO:0005634 nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring possibly expressed 0.29 0.86
Trophozoite expressed 0.48 0.72
Schizont possibly expressed 0.10 0.94
Gametocyte expressed 0.63 0.65

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0410900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.996 | MFS: -2.419 | #Insertions: 1

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0612300)

  • Relative Growth Rate: 0.56 ± 0.18
  • Confidence: 4.86

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0612300)

Modification: Tagged | RMgm-5119

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q9U0H9

"Best" AlphaFill ligand hit: GM6 (gm6001, Local RMSD=0.58) with 4PKW (Global RMSD=28.07)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_105524

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 5 47 19 60
disruptive 52 125 53 147
missense 20 87 43 108

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 12 90 36 61
disruptive 93 225 98 238
missense 39 162 74 147

PlasmoDB Total SNPs: 270

Non-coding: 132 | Synonymous: 57 | Nonsynonymous: 81 | Stop Codon: 0

Protein Information

Protein Length: 977 | Molecular Weight (kDa): 117.528

UniProt ID(s): Q9U0H9

PDB ID(s): None

Isoelectric Point: 6.52

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108
36006241 Composition and organization of kinetochores show plasticity in apicomplexanchromosome segregation Brusini L, Dos Santos Pacheco N, ..., Brochet M 10.1083/jcb.202111084