Product Description: mediator of RNA polymerase II transcription subunit 8, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0016592 | mediator complex |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | possibly expressed | 0.02 | 0.99 |
| Trophozoite | possibly expressed | 0.16 | 0.89 |
| Schizont | not expressed | 0.03 | 0.98 |
| Gametocyte | expressed | 0.14 | 0.91 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0411100
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.12 | MFS: -3.056 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q9U0H7
"Best" AlphaFill ligand hit: SAH (s-adenosyl-l-homocysteine, Local RMSD=5.76) with 7LT5 (Global RMSD=16.15)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_103782
Most Similar Human Ortholog: Q96RU3
TM-align score: 0.36 | RMSD: 4.46
Seq Identity: 0.06 | Length: 107 / 205
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000137942 | formin binding protein 1 like |
| ENSG00000187239 | formin binding protein 1 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 7 | 8 | 9 |
| disruptive | 3 | 6 | 10 | 21 |
| missense | 3 | 6 | 9 | 20 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 13 | 12 | 19 |
| disruptive | 3 | 25 | 20 | 46 |
| missense | 3 | 19 | 19 | 28 |
PlasmoDB Total SNPs: 19
Non-coding: 3 | Synonymous: 14 | Nonsynonymous: 1 | Stop Codon: 1
Protein Length: 205 | Molecular Weight (kDa): 23.965
UniProt ID(s): Q9U0H7
PDB ID(s): None
Isoelectric Point: 6.76
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | N/A | N/A |
| PFam | N/A | N/A |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 35557691 | Mediator Complex of the Malaria Parasite Plasmodium falciparum Associates withEvolutionarily Novel Subunits. | Iyer UB, Park JE, ..., Featherstone M | 10.1021/acsomega.2c00368 |