PF3D7_0411700

Genome location: Pf3D7_04_v3:518,685..519,101(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: MKGLKVFMRSFVYFVLVCNLINNVIIC

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	possibly expressed	0.00	1.00
Trophozoite	not expressed	0.01	1.00
Schizont	not expressed	0.00	1.00
Gametocyte	expressed	0.81	0.69

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0411700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.27 | MFS: 0.191 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q9U0H3

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532761

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	0	6	0	17
disruptive	4	21	8	34
missense	3	20	6	28

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	2	10	7	16
disruptive	13	51	14	46
missense	8	42	10	26

PlasmoDB Total SNPs: 12

Non-coding: 0 | Synonymous: 5 | Nonsynonymous: 7 | Stop Codon: 0

Protein Information

Protein Length: 138 | Molecular Weight (kDa): 16.597

UniProt ID(s): Q9U0H3

PDB ID(s): None

Isoelectric Point: 9.83

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A