PF3D7_0411800

Genome location: Pf3D7_04_v3:519,261..526,401(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.07	0.96
Trophozoite	not expressed	0.71	0.62
Schizont	possibly expressed	0.42	0.77
Gametocyte	not expressed	0.66	0.65

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0411800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.235 | #Insertions: 6

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0613000)

Modification: Disrupted | RMgm-2109

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q9U0H2

"Best" AlphaFill ligand hit: CXS (3-cyclohexyl-1-propylsulfonic acid, Local RMSD=1.65) with 8DOC (Global RMSD=18.10)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_109790

Most Similar Human Ortholog: Q68DL7

TM-align score: 0.17 | RMSD: 8.63

Seq Identity: 0.07 | Length: 195 / 1928

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000206043	chromosome 18 open reading frame 63

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	27	68	42	96
disruptive	91	258	148	306
missense	70	237	138	276

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	37	124	75	113
disruptive	144	523	216	446
missense	100	444	188	332

PlasmoDB Total SNPs: 438

Non-coding: 115 | Synonymous: 186 | Nonsynonymous: 137 | Stop Codon: 0

Protein Information

Protein Length: 1928 | Molecular Weight (kDa): 229.693

UniProt ID(s): Q9U0H2

PDB ID(s): None

Isoelectric Point: 7.07

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR026737	Golgin subfamily A member 6-like
PFam	N/A	N/A
Superfamily	N/A	N/A