PF3D7_0412000

Genome location: Pf3D7_04_v3:536,310..540,069(+)

Genome classification: Core

Function and Localization

Product Description: LITAF-like zinc finger protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.03	0.99
Trophozoite	expressed	0.33	0.79
Schizont	expressed	0.19	0.87
Gametocyte	expressed	0.22	0.87

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0412000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.967 | MFS: -2.729 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q9U0H0

"Best" AlphaFill ligand hit: PXL (3-hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde, Local RMSD=0.05) with 6SU9 (Global RMSD=19.97)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_120882

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	12	28	22	26
disruptive	70	119	48	137
missense	30	77	31	90

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	14	67	19	41
disruptive	104	231	93	233
missense	46	151	62	108

PlasmoDB Total SNPs: 376

Non-coding: 194 | Synonymous: 107 | Nonsynonymous: 74 | Stop Codon: 1

Protein Information

Protein Length: 778 | Molecular Weight (kDa): 92.196

UniProt ID(s): Q9U0H0

PDB ID(s): None

Isoelectric Point: 4.95

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR006629	LPS-induced tumour necrosis factor alpha factor
PFam	PF10601	LPS-induced tumour necrosis factor alpha factor
Superfamily	N/A	N/A