Genome location: Pf3D7_04_v3:539,768..541,690(-)
Genome classification: Core
Product Description: ribosomal protein S12, mitochondrial
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005739 | mitochondrion |
| Component | GO:0005634 | nucleus |
| Component | GO:0005840 | ribosome |
| Component | GO:0015935 | small ribosomal subunit |
| Function | GO:0003735 | structural constituent of ribosome |
| Process | GO:0032543 | mitochondrial translation |
| Process | GO:0009410 | response to xenobiotic stimulus |
| Process | GO:0006412 | translation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.04 | 0.98 |
| Trophozoite | expressed | 0.38 | 0.76 |
| Schizont | possibly expressed | 0.06 | 0.96 |
| Gametocyte | not expressed | 0.12 | 0.92 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0412100
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.385 | MFS: -2.485 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0613400)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q9U0G9
"Best" AlphaFill ligand hit: SRY (streptomycin a, Local RMSD=0.03) with 4DR3 (Global RMSD=2.31)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101451
Most Similar Human Ortholog: O15235
TM-align score: 0.64 | RMSD: 1.86
Seq Identity: 0.45 | Length: 95 / 336
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000128626 | mitochondrial ribosomal protein S12 |
| ENSG00000283018 | mitochondrial ribosomal protein S12 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 8 | 12 | 19 |
| disruptive | 22 | 29 | 12 | 34 |
| missense | 16 | 21 | 9 | 26 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 26 | 14 | 26 |
| disruptive | 30 | 60 | 32 | 76 |
| missense | 22 | 36 | 27 | 55 |
PlasmoDB Total SNPs: 137
Non-coding: 99 | Synonymous: 19 | Nonsynonymous: 19 | Stop Codon: 0
Protein Length: 336 | Molecular Weight (kDa): 39.893
UniProt ID(s): Q9U0G9
PDB ID(s): None
Isoelectric Point: 10.83
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR005679 | Ribosomal protein S12, bacterial-type |
| InterPro | IPR006032 | Ribosomal protein S12/S23 |
| InterPro | IPR012340 | Nucleic acid-binding, OB-fold |
| PFam | PF00164 | Ribosomal protein S12/S23 |
| Superfamily | SSF50249 | Nucleic acid-binding, OB-fold |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 32273345 | Genetic ablation of the mitoribosome in the malaria parasite Plasmodiumfalciparum sensitizes it to antimalarials that target mitochondrial functions. | Ling L, Mulaka M, ..., Ke H | 10.1074/jbc.RA120.012646 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |
| 9434165 | Metazoan nuclear genes for mitoribosomal protein S12 | Shah ZH, O'Dell KM, ..., Jacobs HT | 10.1016/s0378-1119(97)00521-0 |