PF3D7_0412200

Genome location: Pf3D7_04_v3:541,759..543,070(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0044310	osmiophilic body

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.08	0.96
Trophozoite	not expressed	0.15	0.91
Schizont	not expressed	0.02	0.98
Gametocyte	not expressed	0.12	0.92

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0412200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 1 | MFS: -1.531 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0613500)

Relative Growth Rate: 0.05 ± 0.05
Confidence: 7.39

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q9U0G8

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533606

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	8	14	2	8
disruptive	6	23	18	39
missense	6	22	18	37

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	10	17	5	18
disruptive	10	58	43	91
missense	10	52	30	49

PlasmoDB Total SNPs: 38

Non-coding: 23 | Synonymous: 9 | Nonsynonymous: 6 | Stop Codon: 0

Protein Information

Protein Length: 332 | Molecular Weight (kDa): 39.101

UniProt ID(s): Q9U0G8

PDB ID(s): None

Isoelectric Point: 7.92

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
12368867	Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.	Hall N, Pain A, ..., Barrell BG	10.1038/nature01095
27432909	Comparative Proteomics and Functional Analysis Reveal a Role of Plasmodiumfalciparum Osmiophilic Bodies in Malaria Parasite Transmission.	Suarez-Cortes P, Sharma V, ..., Alano P	10.1074/mcp.M116.060681