Product Description: phosphoglucomutase-2
SignalP Peptide: N/A
# Transmembrane Domains: 1
EC Numbers: 5.4.2.2 (Phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent))
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005737 | cytoplasm |
| Component | GO:0005739 | mitochondrion |
| Function | GO:0004619 | phosphoglycerate mutase activity |
| Process | GO:0006096 | glycolytic process |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | possibly expressed | 0.05 | 0.97 |
| Trophozoite | expressed | 0.60 | 0.67 |
| Schizont | expressed | 0.82 | 0.57 |
| Gametocyte | expressed | 0.46 | 0.74 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0413500
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.119 | MFS: -3.017 | #Insertions: 0
PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0715500)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0715500)
Modification: Tagged | RMgm-4962
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I1V2
"Best" AlphaFill ligand hit: POP (pyrophosphate 2-, Local RMSD=1.83) with 5GG7 (Global RMSD=2.79)
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 5.4.2.2 | phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) | ATPAMPGTPCTPUTPEDTACaCl2CoCl2NiCl2citrateisocitratecis-aconitate... |
No evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_104882
Most Similar Human Ortholog: F5GXG4
TM-align score: 0.96 | RMSD: 0.77
Seq Identity: 0.42 | Length: 138 / 295
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000247077 | PGAM family member 5, mitochondrial serine/threonine protein phosphatase |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 6 | 3 | 2 | 7 |
| disruptive | 5 | 7 | 2 | 17 |
| missense | 3 | 6 | 2 | 11 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 7 | 6 | 7 | 12 |
| disruptive | 7 | 28 | 13 | 68 |
| missense | 4 | 17 | 11 | 27 |
PlasmoDB Total SNPs: 63
Non-coding: 45 | Synonymous: 16 | Nonsynonymous: 2 | Stop Codon: 0
Protein Length: 295 | Molecular Weight (kDa): 35.232
UniProt ID(s): Q8I1V2
PDB ID(s): 3EOZ
Isoelectric Point: 9.95
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR013078 | Histidine phosphatase superfamily, clade-1 |
| InterPro | IPR029033 | Histidine phosphatase superfamily |
| PFam | PF00300 | Histidine phosphatase superfamily, clade-1 |
| Superfamily | SSF53254 | Histidine phosphatase superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 21689687 | Characterization of a new phosphatase from Plasmodium. | Hills T, Srivastava A, ..., Pizarro JC | 10.1016/j.molbiopara.2011.06.001 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |
| 35178947 | [Construction of cell factories for high production of ginsenoside Rh_2 inSaccharomyces cerevisiae] | Shi YS, Wang D, ..., Dai ZB | 10.19540/j.cnki.cjcmm.20210914.101 |