PF3D7_0413700

Genome location: Pf3D7_04_v3:619,189..621,405(-)

Genome classification: Core

Function and Localization

Product Description: lysine decarboxylase-like protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: 4.1.1.18 (Lysine decarboxylase)

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005829	cytosol

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	possibly expressed	0.08	0.96
Trophozoite	expressed	0.91	0.53
Schizont	expressed	0.32	0.81
Gametocyte	expressed	0.40	0.77

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0413700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.971 | MFS: -2.569 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I1V0

"Best" AlphaFill ligand hit: AMP (adenosine monophosphate, Local RMSD=0.45) with 5ZBL (Global RMSD=3.20)

BRENDA EC Inhibitors:

EC #	Name	EC Inhibitors
4.1.1.18	lysine decarboxylase	GTPGDPKClPCMBHgCl2L-ArgCaCl2SO42-MnCl2NaBH4FeCl2ppGpp...

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_107817

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	0	12	3	8
disruptive	1	8	5	19
missense	1	8	3	16

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	3	21	8	4
disruptive	2	23	12	29
missense	2	16	8	21

PlasmoDB Total SNPs: 105

Non-coding: 102 | Synonymous: 2 | Nonsynonymous: 1 | Stop Codon: 0

Protein Information

Protein Length: 338 | Molecular Weight (kDa): 39.021

UniProt ID(s): Q8I1V0

PDB ID(s): None

Isoelectric Point: 8.95

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR031100	LOG family
PFam	PF03641	LOG family
Superfamily	SSF102405	N/A