Product Description: structural maintenance of chromosomes protein 3
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0000785 | chromatin |
| Component | GO:0000775 | chromosome, centromeric region |
| Component | GO:0008278 | cohesin complex |
| Component | GO:0000228 | nuclear chromosome |
| Component | GO:0034990 | nuclear mitotic cohesin complex |
| Component | GO:0034399 | nuclear periphery |
| Component | GO:0005634 | nucleus |
| Function | GO:0005524 | ATP binding |
| Function | GO:0019237 | centromeric DNA binding |
| Function | GO:0003682 | chromatin binding |
| Function | GO:0003680 | minor groove of adenine-thymine-rich DNA binding |
| Function | GO:0005515 | protein binding |
| Process | GO:0051276 | chromosome organization |
| Process | GO:0000070 | mitotic sister chromatid segregation |
| Process | GO:0006275 | regulation of DNA replication |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.23 | 0.90 |
| Trophozoite | expressed | 1.41 | 0.36 |
| Schizont | expressed | 0.49 | 0.74 |
| Gametocyte | expressed | 1.42 | 0.33 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0414000
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.142 | MFS: -3.134 | #Insertions: 0
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0716000)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0716000)
Modification: Tagged | RMgm-4672
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I1U7
"Best" AlphaFill ligand hit: AGS (phosphothiophosphoric acid-adenylate ester, Local RMSD=0.51) with 5XG3 (Global RMSD=3.65)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101525
Most Similar Human Ortholog: Q9UQE7
TM-align score: 0.33 | RMSD: 4.55
Seq Identity: 0.34 | Length: 438 / 1193
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000108055 | structural maintenance of chromosomes 3 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 22 | 43 | 29 | 47 |
| disruptive | 12 | 31 | 26 | 75 |
| missense | 12 | 31 | 25 | 68 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 33 | 97 | 28 | 46 |
| disruptive | 20 | 118 | 63 | 206 |
| missense | 14 | 86 | 55 | 163 |
PlasmoDB Total SNPs: 383
Non-coding: 325 | Synonymous: 44 | Nonsynonymous: 14 | Stop Codon: 0
Protein Length: 1193 | Molecular Weight (kDa): 141.225
UniProt ID(s): Q8I1U7
PDB ID(s): None
Isoelectric Point: 6.84
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR003395 | RecF/RecN/SMC, N-terminal |
| InterPro | IPR010935 | SMCs flexible hinge |
| InterPro | IPR024704 | Structural maintenance of chromosomes protein |
| InterPro | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| InterPro | IPR036277 | SMCs flexible hinge superfamily |
| InterPro | IPR038729 | Rad50/SbcC-type AAA domain |
| InterPro | IPR041741 | Structural maintenance of chromosomes 3, ABC domain, eukaryotic |
| PFam | PF02463 | RecF/RecN/SMC, N-terminal |
| PFam | PF06470 | SMCs flexible hinge |
| PFam | PF13476 | Rad50/SbcC-type AAA domain |
| Superfamily | SSF52540 | P-loop containing nucleoside triphosphate hydrolase |
| Superfamily | SSF75553 | SMCs flexible hinge superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 32017676 | The chromatin bound proteome of the human malaria parasite | Batugedara G, Lu XM, ..., Le Roch KG | 10.1099/mgen.0.000327 |