PF3D7_0414200 (PLC3)

Genome location: Pf3D7_04_v3:646,996..648,777(-)

Genome classification: Core

Function and Localization

Product Description: calmodulin-like protein

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Function	GO:0005515	protein binding

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	nd	nd
Trophozoite	no data	nd	nd
Schizont	no data	nd	nd
Gametocyte	no data	nd	nd

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0414200.2

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.131 | MFS: -3.125 | #Insertions: 0

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0716200)

Relative Growth Rate: 0.57 ± 0.21
Confidence: 4.47

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0716200)

Modification: Disrupted | RMgm-2254

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A143ZWH4

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_146108

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	5	8	3	7
disruptive	2	8	5	14
missense	2	8	5	12

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	6	14	1	7
disruptive	4	14	13	22
missense	4	12	10	15

PlasmoDB Total SNPs: 70

Non-coding: 62 | Synonymous: 7 | Nonsynonymous: 1 | Stop Codon: 0

Protein Information

Protein Length: 150 | Molecular Weight (kDa): 17.729

UniProt ID(s): C0H4A2

PDB ID(s): None

Isoelectric Point: 4.58

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR011992	EF-hand domain pair
PFam	N/A	N/A
Superfamily	SSF47473	EF-hand domain pair