Product Description: Rab5-interacting protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 3
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0072546 | EMC complex |
| Component | GO:0005739 | mitochondrion |
| Process | GO:0000045 | autophagosome assembly |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | no data | N/A | N/A |
| Ring | no data | 0.09 | 0.96 |
| Trophozoite | no data | 0.26 | 0.83 |
| Schizont | no data | 0.05 | 0.96 |
| Gametocyte | no data | 0.16 | 0.91 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0414300
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.59 | MFS: -2.141 | #Insertions: 0
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0716300)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0716300)
Modification: Disrupted | RMgm-2255
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C0H4A3
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_104671
Most Similar Human Ortholog: A0A0A6YYL0
TM-align score: 0.64 | RMSD: 2.26
Seq Identity: 0.21 | Length: 90 / 112
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000101084 | RAB5 interacting factor |
| ENSG00000259399 | TGIF2-RAB5IF readthrough |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 2 | 4 | 5 |
| disruptive | 1 | 4 | 5 | 13 |
| missense | 1 | 4 | 5 | 10 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 10 | 4 | 3 |
| disruptive | 5 | 18 | 11 | 21 |
| missense | 2 | 15 | 7 | 14 |
PlasmoDB Total SNPs: 71
Non-coding: 53 | Synonymous: 18 | Nonsynonymous: 0 | Stop Codon: 0
Protein Length: 112 | Molecular Weight (kDa): 13.208
UniProt ID(s): C0H4A3
PDB ID(s): None
Isoelectric Point: 9.63
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR008504 | ER membrane protein complex subunit 6 |
| InterPro | IPR029008 | Rab5-interacting protein family |
| PFam | PF07019 | Rab5-interacting protein family |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |