PF3D7_0414400

Genome location: Pf3D7_04_v3:652,350..653,554(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.01	1.00
Trophozoite	not expressed	0.01	0.99
Schizont	not expressed	0.01	1.00
Gametocyte	not expressed	0.08	0.95

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0414400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.945 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PBANKA_0716400)

Modification: Disrupted | RMgm-304

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I1U4

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533401

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	18	7	22
disruptive	12	45	19	66
missense	10	34	13	60

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	5	25	13	20
disruptive	39	103	38	69
missense	18	73	33	40

PlasmoDB Total SNPs: 58

Non-coding: 39 | Synonymous: 3 | Nonsynonymous: 16 | Stop Codon: 0

Protein Information

Protein Length: 330 | Molecular Weight (kDa): 38.359

UniProt ID(s): Q8I1U4

PDB ID(s): None

Isoelectric Point: 10.63

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A