Product Description: acylated pleckstrin-homology domain-containing protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0045177 | apical part of cell |
| Component | GO:0020009 | microneme |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | not expressed | 0.06 | 0.97 |
| Trophozoite | expressed | 0.38 | 0.77 |
| Schizont | expressed | 0.89 | 0.50 |
| Gametocyte | expressed | 0.45 | 0.74 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0414600
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.677 | MFS: -2.209 | #Insertions: 0
PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0716600)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PY17X_0716800)
Modification: Mutated | RMgm-5099
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I1U2
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 7 | 4 | 7 |
| disruptive | 4 | 6 | 7 | 15 |
| missense | 3 | 4 | 6 | 9 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 9 | 9 | 12 |
| disruptive | 6 | 22 | 14 | 38 |
| missense | 3 | 12 | 12 | 23 |
PlasmoDB Total SNPs: 163
Non-coding: 158 | Synonymous: 3 | Nonsynonymous: 2 | Stop Codon: 0
Protein Length: 235 | Molecular Weight (kDa): 27.354
UniProt ID(s): Q8I1U2
PDB ID(s): None
Isoelectric Point: 7.11
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001849 | Pleckstrin homology domain |
| PFam | PF00169 | Pleckstrin homology domain |
| Superfamily | SSF50729 | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 20037583 | Transcriptional profiling of growth perturbations of the human malaria parasitePlasmodium falciparum. | Hu G, Cabrera A, ..., Bozdech Z | 10.1038/nbt.1597 |
| 27594426 | A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential ApicomplexanGenes. | Sidik SM, Huet D, ..., Lourido S | 10.1016/j.cell.2016.08.019 |
| 34628068 | Distinct effects on the secretion of MTRAP and AMA1 in Plasmodium yoeliifollowing deletion of acylated pleckstrin homology domain-containing protein. | Chaiyawong N, Ishizaki T, ..., Kaneko O | 10.1016/j.parint.2021.102479 |