Product Description: armadillo-domain containing rhoptry protein
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0031225 | anchored component of membrane |
| Component | GO:0045177 | apical part of cell |
| Component | GO:0005829 | cytosol |
| Component | GO:0005634 | nucleus |
| Component | GO:0020008 | rhoptry |
| Function | GO:0003677 | DNA binding |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | expressed | 0.27 | 0.89 |
| Trophozoite | expressed | 0.02 | 0.99 |
| Schizont | expressed | 0.67 | 0.72 |
| Gametocyte | expressed | 0.02 | 0.99 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0414900
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.682 | MFS: -2.214 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C0H4A5
"Best" AlphaFill ligand hit: B3P (2-[3-(2-hydroxy-1,1-dihydroxymethyl-ethylamino)-propylamino]-2-hydroxymethyl-propane-1,3-diol, Local RMSD=2.01) with 5XJG (Global RMSD=4.01)
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 17 | 9 | 15 |
| disruptive | 1 | 4 | 1 | 10 |
| missense | 1 | 4 | 1 | 7 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 29 | 15 | 13 |
| disruptive | 2 | 9 | 11 | 37 |
| missense | 2 | 6 | 9 | 25 |
PlasmoDB Total SNPs: 218
Non-coding: 208 | Synonymous: 6 | Nonsynonymous: 3 | Stop Codon: 1
Protein Length: 275 | Molecular Weight (kDa): 30.818
UniProt ID(s): C0H4A5
PDB ID(s): None
Isoelectric Point: 4.76
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR016024 | Armadillo-type fold |
| PFam | N/A | N/A |
| Superfamily | SSF48371 | Armadillo-type fold |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 20037583 | Transcriptional profiling of growth perturbations of the human malaria parasitePlasmodium falciparum. | Hu G, Cabrera A, ..., Bozdech Z | 10.1038/nbt.1597 |
| 22759070 | Dissection of minimal sequence requirements for rhoptry membrane targeting in themalaria parasite. | Cabrera A, Herrmann S, ..., Gilberger TW | 10.1111/j.1600-0854.2012.01394.x |
| 26828945 | Evidence for the Nucleo-Apical Shuttling of a Beta-Catenin Like Plasmodiumfalciparum Armadillo Repeat Containing Protein. | Mitra P, Gupta ED, ..., Gaur D | 10.1371/journal.pone.0148446 |
| 31877322 | Structural Insights Into PfARO and Characterization of its Interaction WithPfAIP. | Geiger M, Brown C, ..., Gilberger TW | 10.1016/j.jmb.2019.12.024 |