PF3D7_0415200

Genome location: Pf3D7_04_v3:672,035..679,718(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	possibly expressed	0.16	0.92
Trophozoite	expressed	1.00	0.50
Schizont	expressed	0.33	0.82
Gametocyte	expressed	0.62	0.70

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0415200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 18 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.623 | #Insertions: 13

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0717200)

Relative Growth Rate: 0.07 ± 0.12
Confidence: 5.57

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I1T6

"Best" AlphaFill ligand hit: 1PG (2-(2-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethanol, Local RMSD=1.82) with 5FRE (Global RMSD=13.19)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_116085

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	16	76	33	100
disruptive	117	281	128	288
missense	63	174	85	207

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	28	140	53	101
disruptive	217	494	223	441
missense	101	320	152	283

PlasmoDB Total SNPs: 489

Non-coding: 114 | Synonymous: 218 | Nonsynonymous: 157 | Stop Codon: 0

Protein Information

Protein Length: 2212 | Molecular Weight (kDa): 261.821

UniProt ID(s): Q8I1T6

PDB ID(s): None

Isoelectric Point: 8.83

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
12368867	Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.	Hall N, Pain A, ..., Barrell BG	10.1038/nature01095
16267556	A protein interaction network of the malaria parasite Plasmodium falciparum.	LaCount DJ, Vignali M, ..., Hughes RE	10.1038/nature04104