About Gene List

PF3D7_0415700

Genome location: Pf3D7_04_v3:690,721..692,635(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020011 apicoplast

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite possibly expressed N/A N/A
Ring possibly expressed 0.13 0.93
Trophozoite expressed 0.43 0.74
Schizont expressed 0.50 0.73
Gametocyte possibly expressed 0.17 0.90

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0415700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.122 | MFS: -3 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I1T0

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532387

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 5 12 6 21
disruptive 9 23 24 55
missense 7 15 14 36

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 6 25 16 23
disruptive 20 95 62 117
missense 9 42 42 65

PlasmoDB Total SNPs: 102

Non-coding: 41 | Synonymous: 47 | Nonsynonymous: 14 | Stop Codon: 0

Protein Information

Protein Length: 461 | Molecular Weight (kDa): 55.987

UniProt ID(s): Q8I1T0

PDB ID(s): None

Isoelectric Point: 9.76

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
30212465 Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites. Boucher MJ, Ghosh S, ..., Yeh E 10.1371/journal.pbio.2005895