About Gene List

PF3D7_0415800

Genome location: Pf3D7_04_v3:693,250..696,792(+)

Genome classification: Core

Function and Localization

Product Description: PhIL1-interacting candidate PIC3

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0070258 inner membrane pellicle complex
Function GO:0008270 zinc ion binding

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.21 0.92
Trophozoite not expressed 0.13 0.92
Schizont not expressed 0.72 0.72
Gametocyte not expressed 0.31 0.82

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0415800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.641 | #Insertions: 5

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I1S9

"Best" AlphaFill ligand hit: CPQ (n,n-bis(3-d-gluconamidopropyl)deoxycholamide, Local RMSD=0.45) with 4AYC (Global RMSD=20.26)

No associated EC numbers

Orthology to BindingDB Entries:

UniProt Protein Name Species Homology Source BindingDB Ligands
Q9Y508 E3 ubiquitin-protein ligase RNF114 OrthoMCL BLAST CHEMBL5218793

Orthology Information

Ortholog Group (OrthoMCL): OG6_138039

No human ortholog(s)

Protein Information

Protein Length: 875 | Molecular Weight (kDa): 106.504

UniProt ID(s): Q8I1S9

PDB ID(s): None

Isoelectric Point: 8.89

Protein Domain Annotations:

Source Family ID Description
InterPro IPR001841 Zinc finger, RING-type
InterPro IPR017907 Zinc finger, RING-type, conserved site
PFam PF13923 N/A
Superfamily SSF57850 N/A

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 11 19 20 29
disruptive 65 91 40 133
missense 26 59 33 97

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 14 48 28 53
disruptive 99 185 106 214
missense 43 120 77 136

PlasmoDB Total SNPs: 188

Non-coding: 66 | Synonymous: 73 | Nonsynonymous: 48 | Stop Codon: 1

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
33830607 Identification of novel inner membrane complex and apical annuli proteins of themalaria parasite Plasmodium falciparum. Wichers JS, Wunderlich J, ..., Gilberger TW 10.1111/cmi.13341