Product Description: 60S ribosomal protein L15, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0022625 | cytosolic large ribosomal subunit |
| Component | GO:0005634 | nucleus |
| Component | GO:0005840 | ribosome |
| Function | GO:0003723 | RNA binding |
| Function | GO:0003735 | structural constituent of ribosome |
| Process | GO:0002181 | cytoplasmic translation |
| Process | GO:0006412 | translation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 1.72 | 0.34 |
| Trophozoite | expressed | 1.95 | 0.22 |
| Schizont | expressed | 0.40 | 0.77 |
| Gametocyte | expressed | 1.05 | 0.48 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0415900
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.123 | MFS: -2.823 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0717800)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C0H4A6
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100733
Most Similar Human Ortholog: A0A2R8YEM3
TM-align score: 1.00 | RMSD: 0.35
Seq Identity: 0.67 | Length: 169 / 205
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000174738 | nuclear receptor subfamily 1 group D member 2 |
| ENSG00000174748 | ribosomal protein L15 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 0 | 0 | 0 |
| disruptive | 1 | 0 | 0 | 0 |
| missense | 0 | 0 | 0 | 0 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 0 | 0 | 0 |
| disruptive | 1 | 0 | 0 | 0 |
| missense | 0 | 0 | 0 | 0 |
PlasmoDB Total SNPs: 149
Non-coding: 144 | Synonymous: 4 | Nonsynonymous: 1 | Stop Codon: 0
Protein Length: 205 | Molecular Weight (kDa): 24.134
UniProt ID(s): C0H4A6
PDB ID(s): 3J79, 3JBN, 3JBO, 3JBP, 5UMD
Isoelectric Point: 11.83
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000439 | Ribosomal protein L15e |
| InterPro | IPR012678 | Ribosomal protein L23/L15e core domain superfamily |
| InterPro | IPR020925 | Ribosomal protein L15e, conserved site |
| PFam | PF00827 | Ribosomal protein L15e |
| Superfamily | SSF54189 | Ribosomal protein L23/L15e core domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |