About Gene List

PF3D7_0416000

Genome location: Pf3D7_04_v3:700,633..705,339(-)

Genome classification: Core

Function and Localization

Product Description: RNA-binding protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Function GO:0003723 RNA binding
Function GO:0003676 nucleic acid binding

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring expressed 0.22 0.90
Trophozoite expressed 0.81 0.57
Schizont expressed 0.89 0.52
Gametocyte expressed 1.12 0.45

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0416000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: 0.692 | #Insertions: 9

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0717900)

Modification: Disrupted | RMgm-2265

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I1S7

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532880

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 7 20 13 37
disruptive 21 42 33 118
missense 11 25 23 101

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 10 40 22 37
disruptive 34 121 59 138
missense 15 78 47 108

PlasmoDB Total SNPs: 283

Non-coding: 225 | Synonymous: 37 | Nonsynonymous: 21 | Stop Codon: 0

Protein Information

Protein Length: 579 | Molecular Weight (kDa): 65.938

UniProt ID(s): Q8I1S7

PDB ID(s): None

Isoelectric Point: 10.38

Protein Domain Annotations:

Source Family ID Description
InterPro IPR000504 RNA recognition motif domain
InterPro IPR035979 RNA-binding domain superfamily
PFam PF00076 RNA recognition motif domain
Superfamily SSF101447 RNA-binding domain superfamily
Superfamily SSF54928

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104