Product Description: RNA-binding protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
Type | GO Term | Name |
---|---|---|
Function | GO:0003723 | RNA binding |
Function | GO:0003676 | nucleic acid binding |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
Stage | LR class | MCA mean | MCA prop. zeros |
---|---|---|---|
Sporozoite | expressed | N/A | N/A |
Ring | expressed | 0.22 | 0.90 |
Trophozoite | expressed | 0.81 | 0.57 |
Schizont | expressed | 0.89 | 0.52 |
Gametocyte | expressed | 1.12 | 0.45 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0416000
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: 0.692 | #Insertions: 9
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0717900)
Modification: Disrupted | RMgm-2265
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I1S7
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 7 | 20 | 13 | 37 |
disruptive | 21 | 42 | 33 | 118 |
missense | 11 | 25 | 23 | 101 |
Any inclusion in genotype call
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 10 | 40 | 22 | 37 |
disruptive | 34 | 121 | 59 | 138 |
missense | 15 | 78 | 47 | 108 |
PlasmoDB Total SNPs: 283
Non-coding: 225 | Synonymous: 37 | Nonsynonymous: 21 | Stop Codon: 0
Protein Length: 579 | Molecular Weight (kDa): 65.938
UniProt ID(s): Q8I1S7
PDB ID(s): None
Isoelectric Point: 10.38
Protein Domain Annotations:
Source | Family ID | Description |
---|---|---|
InterPro | IPR000504 | RNA recognition motif domain |
InterPro | IPR035979 | RNA-binding domain superfamily |
PFam | PF00076 | RNA recognition motif domain |
Superfamily | SSF101447 | RNA-binding domain superfamily |
Superfamily | SSF54928 |
PMID | Title | Authors | DOI/Link |
---|---|---|---|
12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |