Product Description: PRKR-interacting protein 1, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005730 | nucleolus |
| Function | GO:0003725 | double-stranded RNA binding |
| Function | GO:0019901 | protein kinase binding |
| Function | GO:0004860 | protein kinase inhibitor activity |
| Process | GO:0006469 | negative regulation of protein kinase activity |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.43 | 0.80 |
| Trophozoite | expressed | 0.21 | 0.87 |
| Schizont | expressed | 0.24 | 0.87 |
| Gametocyte | not expressed | 0.18 | 0.89 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0416200
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.431 | MFS: -2.452 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I1S5
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 4 | 3 | 11 |
| disruptive | 1 | 7 | 7 | 23 |
| missense | 1 | 6 | 7 | 19 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 9 | 4 | 15 |
| disruptive | 4 | 26 | 17 | 43 |
| missense | 2 | 15 | 14 | 33 |
PlasmoDB Total SNPs: 88
Non-coding: 83 | Synonymous: 2 | Nonsynonymous: 3 | Stop Codon: 0
Protein Length: 207 | Molecular Weight (kDa): 24.416
UniProt ID(s): Q8I1S5
PDB ID(s): None
Isoelectric Point: 5.68
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR009548 | PRKR-interacting protein 1 |
| PFam | PF06658 | PRKR-interacting protein 1 |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |