Product Description: histone acetyltransferase, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 2.3.1.48 (Histone acetyltransferase)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005634 | nucleus |
| Function | GO:0010485 | H4 histone acetyltransferase activity |
| Process | GO:0043967 | histone H4 acetylation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | possibly expressed | 0.15 | 0.93 |
| Trophozoite | expressed | 0.95 | 0.52 |
| Schizont | expressed | 1.01 | 0.50 |
| Gametocyte | expressed | 0.44 | 0.75 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0416400
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.401 | MFS: -2.625 | #Insertions: 0
PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0718400)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0718400)
Modification: Disrupted | RMgm-2268
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C0H4A7
"Best" AlphaFill ligand hit: CO6 (ib-co6, Local RMSD=10.44) with 6VO5 (Global RMSD=17.17)
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 2.3.1.48 | histone acetyltransferase | CoADNARNABF1EDTAMB-3LTK14PU139A-485TTK21CPTH2CPTH6... |
No evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102175
Most Similar Human Ortholog: O14929
TM-align score: 0.78 | RMSD: 3.31
Seq Identity: 0.25 | Length: 374 / 1259
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000128708 | histone acetyltransferase 1 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 26 | 27 | 64 |
| disruptive | 32 | 86 | 41 | 134 |
| missense | 14 | 62 | 32 | 108 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 7 | 69 | 36 | 69 |
| disruptive | 62 | 160 | 106 | 285 |
| missense | 28 | 117 | 78 | 188 |
PlasmoDB Total SNPs: 192
Non-coding: 113 | Synonymous: 54 | Nonsynonymous: 25 | Stop Codon: 0
Protein Length: 1259 | Molecular Weight (kDa): 146.726
UniProt ID(s): C0H4A7
PDB ID(s): None
Isoelectric Point: 6.61
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR016181 | Acyl-CoA N-acyltransferase |
| InterPro | IPR017380 | Histone acetyltransferase type B, catalytic subunit |
| InterPro | IPR019467 | Histone acetyl transferase HAT1 N-terminal |
| PFam | PF10394 | Histone acetyl transferase HAT1 N-terminal |
| Superfamily | SSF55729 | Acyl-CoA N-acyltransferase |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 38345235 | An Acetyl-Click Chemistry Assay to Measure Histone Acetyltransferase 1Acetylation | Rajkumar S, Dixon D, Lipchik AM, Gruber JJ | 10.3791/66054 |