Product Description: repressor of RNA polymerase III transcription MAF1
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005737 | cytoplasm |
| Component | GO:0005634 | nucleus |
| Function | GO:0000994 | RNA polymerase III core binding |
| Process | GO:0016480 | negative regulation of transcription by RNA polymerase III |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.07 | 0.97 |
| Trophozoite | possibly expressed | 0.60 | 0.68 |
| Schizont | expressed | 1.02 | 0.49 |
| Gametocyte | expressed | 1.33 | 0.37 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0416500
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.134 | MFS: -2.987 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I1S2
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102476
Most Similar Human Ortholog: Q9H063
TM-align score: 0.59 | RMSD: 3.74
Seq Identity: 0.23 | Length: 184 / 389
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000179632 | MAF1 homolog, negative regulator of RNA polymerase III |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 4 | 1 | 7 |
| disruptive | 4 | 20 | 9 | 30 |
| missense | 2 | 12 | 6 | 25 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 6 | 11 | 21 |
| disruptive | 15 | 40 | 43 | 91 |
| missense | 6 | 21 | 33 | 57 |
PlasmoDB Total SNPs: 46
Non-coding: 9 | Synonymous: 20 | Nonsynonymous: 17 | Stop Codon: 0
Protein Length: 389 | Molecular Weight (kDa): 46.498
UniProt ID(s): Q8I1S2
PDB ID(s): None
Isoelectric Point: 4.34
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR015257 | Repressor of RNA polymerase III transcription Maf1 |
| PFam | PF09174 | Repressor of RNA polymerase III transcription Maf1 |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 28351924 | Plasmodium falciparum Maf1 Confers Survival upon Amino Acid Starvation | McLean KJ, Jacobs-Lorena M | 10.1128/mBio.02317-16 |
| 36794724 | Cellular responses to long-term phosphate starvation of fission yeast: Maf1determines fate choice between quiescence and death associated with aberrant tRNAbiogenesis | Garg A, Sanchez AM, ..., Shuman S | 10.1093/nar/gkad063 |