Product Description: prohibitin-like protein PHBL, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005739 | mitochondrion |
| Process | GO:0051881 | regulation of mitochondrial membrane potential |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.09 | 0.96 |
| Trophozoite | possibly expressed | 0.67 | 0.63 |
| Schizont | possibly expressed | 0.13 | 0.91 |
| Gametocyte | possibly expressed | 0.56 | 0.70 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0416600
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.12 | MFS: -2.978 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0718600)
Modification: Disrupted | RMgm-4447
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I1S1
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 1 | 1 | 6 |
| disruptive | 8 | 11 | 10 | 25 |
| missense | 4 | 8 | 9 | 23 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 6 | 10 | 7 |
| disruptive | 12 | 40 | 16 | 65 |
| missense | 5 | 28 | 14 | 36 |
PlasmoDB Total SNPs: 165
Non-coding: 146 | Synonymous: 11 | Nonsynonymous: 8 | Stop Codon: 0
Protein Length: 287 | Molecular Weight (kDa): 34.624
UniProt ID(s): Q8I1S1
PDB ID(s): None
Isoelectric Point: 8.88
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | N/A | N/A |
| PFam | N/A | N/A |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 29669282 | An Unusual Prohibitin Regulates Malaria Parasite Mitochondrial MembranePotential. | Matz JM, Goosmann C, Matuschewski K, Kooij TWA | 10.1016/j.celrep.2018.03.088 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |